Introduction
It
is well known that a substance can be in one of the four possible physical phases, viz.
solid, liquid, gas, and plasma, depending upon a set of physical parameters called
temperature and pressure. Thus a given substance is inherently not solid, liquid, gas, or
plasma; it is solid, liquid, gas, or plasma, depending upon the status of intro-external
environment in which it lives; the intro-external environment in this case is represented
by a set of physical parameters called temperature and pressure, temperature representing
the internal environment and pressure representing the external environment.
Taking
a clue from physical-phasing related analogies and in order to explain certain drug
characteristics, a new concept of interactive phases of drugs is introduced in this paper;
the word "drug" here includes any material normally understood as a medicine,
nutrient, or poison.
It
is proposed here that a drug in an organ of a living body can be in one of the three
possible interactive phases, viz. medical phase (M phase), nutritive phase (N phase), and
poisonous phase (P phase), depending upon a set of interactive parameters called quantity
and health. Thus a given drug is inherently not medicine, nutrient, or poison; it is
medicine, nutrient, or poison, depending upon the status of intro-external environment in
which it lives; the intro-external environment in this case is represented by a set of
interactive parameters called quantity and health, quantity representing the internal
environment and health representing the external environment.
Tube
Flow Analogies for Drug Phases
Let
us consider a liquid flowing through a solid-walled tube. If a little air is blown onto
this flowing liquid (Fig l a). the air acts as an external factor to intensify the liquid
flow. If much air is blown (Fig lb), the air and liquid act together as a mixture flowing
through the tube. If too much air is blown (Fig l c), the air not only disrupts the flow
of liquid but also tends to damage the tube. In this way, whether the air acts as a useful
flow-supporting mechanism. or as a to-be-flown medium, or as a
flow-and-the-tube-disrupting device, depends on whether the air quantity is small or
medium or high.
An
organ of a living body is similar to the solid-walled tube of this analogy (of gas on
liquid in solid); nutrient material inside this organ is similar to the liquid flowing
through the tube; a drug taken inside the organ is similar to the air blown onto the
liquid into the tube. The behavior characteristic with respect to the dose volume in the
case of a drug is similar to the behavioral characteristic with respect to the dose volume
in the case of air into a tube. Whether the drug acts as a useful nutrient-support
mechanism, or as a nutrient part, or as a nutrient-and-organ-damaging device, depends on
whether the drug quantity is small or medium or high.
Let
us now reconsider a liquid flowing through a solid-walled tube. If a little air is blown
onto this flowing liquid (Fig 2a), the air acts as an external factor to intensify the
liquid flow. Instead of air, if some other liquid is blown into the flowing liquid (Fig
2b), the external liquid mixes with the flowing liquid and the mixture as a whole flows
through the tube. Instead of air or liquid, if a solid block is inserted into the flowing
liquid (Fig 2c), the solid block not only acts as an obstacle to the liquid flow but it
also tends to damage the tube. In this way, whether the external induction acts as a
useful flow-supporting mechanism, or as a to-be-flown medium, or as a
flow-and-tube-disrupting device, depends onwhether the external inductor is in the gaseous
phase, or liquid phase, or solid phase.
Just
as in the case of the foregoing analogy (of gas on liquid in solid), an organ of a living
body is similar to the solid-walled tube of the new analogy (of gas/liquid/solid on liquid
in solid); nutrient inside the organ is similar to the liquid flowing through the tube; a
drug taken inside the organ is similar to the external inductor blown onto the liquid into
the tube. The behavior characteristic with respect to the dose volume in the case of a
drug in an organ is similar to the behavior characteristic with respect to the phase in
the case of an external inductor into a tube.
Transitions
of Drug Phases
Let
us now compare the first analogy (of gas on liquid in solid) with the second analogy (of
gas/liquid/solid on liquid in solid). If a drug is little in quantity, it acts as a
medicine; this phase of the drug is akin to the little-gas phase of the inductor of the
first analogy and the gaseous phase of the inductor of the second analogy. If the drug is
much in quantity, it acts as a nutrient; this phase of the drug is akin to the much-gas
phase of the inductor of the first analogy and the liquid phase of the inductor of the
second analogy. If the drug is too much in quantity, it acts as a poison; this phase of
the drug is akin to the too-much-gas phase of the inductor of the first analogy and the
solid phase of the inductor of the second analogy.
Relative
density of the drug may be defined as the ratio of mass of the drug to volume of the organ
to be acted upon. The drug is in a gas-like (medical) or liquid-like (nutritive) or
solid-like (poisonous) phase depending upon whether the drug relative density is small or
medium or high.
For
a gas to become a liquid, more of gas molecules have to be pumped into the same volume to
enhance the density. Similarly for a drug to transit from its gas-like medical phase to
its liquid-like nutritive phase, more of drug molecules have to be pumped into the organ.
For
a liquid to become a solid, more of liquid molecules have to be pumped into the same
volume to enhance the density. Similarly for a drug to transit from its liquid-like
nutritive phase to its solid-like poisonous phase, more of drug molecules have to be
pumped into the organ.
Coherence-Tension
Theory for Drug Phases
When
an external drug is taken into a living body, the drug comes across a body organ and an
internal nutrient working inside/for the organ. Characteristics of interaction of the drug
on the internal nutrient and the organ depend inter-alia upon the drug quantity. This
dependence can be explained as follows on the basis of coherence and tension. The
explanation employs a provable assumption that the action of a material on another
material leads to an equal reaction involving rearrangement of the reacting material in
the form of revised units numbering equal to the number of units of the acting material;
the unit being used to indicate a coherent base structure.
Until
the drug quantity is relatively less than the internal nutrient quantity (Fig 3a), the
drug consists of very few drug units. The conglomeration of the organ and the internal
nutrient, which so far had numerous O-phase units, now gets rearranged into very few
M-phase units, with each M-phase unit consisting of many O-phase units. This leads to a
coherence and unification of O-phase units of the internal nutrient and the organ, and the
internal nutrient and the organ undergo a cooperative tension to combat the drug
penetration. Under this condition of cooperative tension, the effectiveness of the
internal nutrient towards the organ is enhanced, and the organ being under a concentrated
attention towards the internal nutrient undergoes suppression of the effect of painful
subunits and thereby a healing process. Here energy flows from the paining component of
the organ to the interjoint of the internal nutrient and the organ. This is the medical
phase (M phase) of the drug, in which the drug shows actions like a medicine for the
organ.
When
the drug quantity becomes relatively comparable with the internal nutrient quantity (Fig
3b), the number of drug units increases. The conglomeration of the organ and the internal
nutrient, which so far had very few M-phase units, now gets rearranged into several
N-phase units, with each M-phase unit divided into several N-phase units and the number of
N-phase units being comparable to the number of drug units. This reduces the coherence and
unification of the internal nutrient and the organ, and the internal nutrient undergoes an
internal tension to absorb the drug and the organ is left to its own course. Under this
condition of internal tension, the strength of the internal nutrient as a nutrient for the
organ is supplemented by an absorption of the drug, and the organ being under a forced
attention towards itself is unable to undergo any healing process. Here energy flows from
the drug to the internal nutrient. This is the nutritive phase (N phase) of the drug, in
which the drug stops showing actions like a medicine and instead shows actions like a
nutrient for the organ.
When
the drug quantity becomes relatively higher than the internal nutrient quantity (Fig 3c),
the number of drug units becomes sizable. The conglomeration of the organ and the internal
nutrient, which so far had several N-phase units, now gets fragmented into large number of
P-phase units, with each N-phase unit divided into several P-phase units and the number of
P-phase units being comparable to the number of units of the drug. This enhances the
incoherence and division of the internal nutrient and the drug, and the drug exerts a
reverse tension to absorb the internal nutrient along with the organ. Under this condition
of reverse tension, the strength of the internal nutrient as a nutrient for the organ is
destroyed because of the absorption by the drug, and the organ being under an attack-like
absorption by the drug undergoes a destruction process. Here energy flows from the organ
to the drug. This is the poisonous phase (P phase) of the drug, in which the drug stops
showing actions like a medicine or nutrient and instead shows actions like poison for the
organ.
Implications
of the Proposal
It
is known in homeopathy that an inorganic or organic material acts as a medicine if it is
taken below a certain limit by a patient suffering from a certain disease, but the same
inorganic or organic material acts as a poison if it is taken above a certain limit by a
healthy person. The proposal presented in this paper throws some light on this
so-far-unexplained "homeopathic phenomenon". In fact this homeopathic phenomenon
may be viewed just as a special case of the medical-nutritive-poisonous (MNP) phasing of a
drug in an organ.
Besides
this, the following important implications follow from the present proposal:
Little-more-than-prescribed
medicine acts as a nutrient and does not harm.
Too
much medicine acts as a poison and deteriorates the body and hence must be avoided.
More-than-starving
but less-than-desired food acts as a medicine and keeps the body healthy.
More-than-enough
food acts as a poison and deteriorates the body and must be avoided.
Little
alcohol is very useful, some alcohol good, much alcohol is harmful.
Intake
of nominal quantity of poison may improve health.
The
medical practice should be more control oriented and less consumption oriented.
Figure 1: Air on Liquid in Solid
Case a: Little Air; Case b: Much Air; Case c: Too Much Air

Figure 2: Air / Liquid / Solid on Liquid in Solid
Case a: Air; Case b: Liquid; Case c: Solid

Figure 3: Drug on Nutrient in Organ
Case a: Little Drug; Case b: Much Drug; Case c: Too Much Drug

References
The
Feynman Lectures on Physics (RP Feynman, RB Leighton, M Sands) Addison Wesley 1965
Biophysics-
Concepts and Mechanisms (EJ Casey) VanNostrand Reinhold 1962
Chemobiodynamics
and Drug Design (FW Scheuler) McGraw Hill 1961
Histones
as Regulators of Genes (M Grunstein) Scientific American 267/4, p 68, 1992
|