Medical Nutritive Poisonous Phases of Drugs in Organs

Lalit A Patel

Introduction

It is well known that a substance can be in one of the four possible physical phases, viz. solid, liquid, gas, and plasma, depending upon a set of physical parameters called temperature and pressure. Thus a given substance is inherently not solid, liquid, gas, or plasma; it is solid, liquid, gas, or plasma, depending upon the status of intro-external environment in which it lives; the intro-external environment in this case is represented by a set of physical parameters called temperature and pressure, temperature representing the internal environment and pressure representing the external environment.

Taking a clue from physical-phasing related analogies and in order to explain certain drug characteristics, a new concept of interactive phases of drugs is introduced in this paper; the word "drug" here includes any material normally understood as a medicine, nutrient, or poison.

It is proposed here that a drug in an organ of a living body can be in one of the three possible interactive phases, viz. medical phase (M phase), nutritive phase (N phase), and poisonous phase (P phase), depending upon a set of interactive parameters called quantity and health. Thus a given drug is inherently not medicine, nutrient, or poison; it is medicine, nutrient, or poison, depending upon the status of intro-external environment in which it lives; the intro-external environment in this case is represented by a set of interactive parameters called quantity and health, quantity representing the internal environment and health representing the external environment.

Tube Flow Analogies for Drug Phases

Let us consider a liquid flowing through a solid-walled tube. If a little air is blown onto this flowing liquid (Fig l a). the air acts as an external factor to intensify the liquid flow. If much air is blown (Fig lb), the air and liquid act together as a mixture flowing through the tube. If too much air is blown (Fig l c), the air not only disrupts the flow of liquid but also tends to damage the tube. In this way, whether the air acts as a useful flow-supporting mechanism. or as a to-be-flown medium, or as a flow-and-the-tube-disrupting device, depends on whether the air quantity is small or medium or high.

An organ of a living body is similar to the solid-walled tube of this analogy (of gas on liquid in solid); nutrient material inside this organ is similar to the liquid flowing through the tube; a drug taken inside the organ is similar to the air blown onto the liquid into the tube. The behavior characteristic with respect to the dose volume in the case of a drug is similar to the behavioral characteristic with respect to the dose volume in the case of air into a tube. Whether the drug acts as a useful nutrient-support mechanism, or as a nutrient part, or as a nutrient-and-organ-damaging device, depends on whether the drug quantity is small or medium or high.

Let us now reconsider a liquid flowing through a solid-walled tube. If a little air is blown onto this flowing liquid (Fig 2a), the air acts as an external factor to intensify the liquid flow. Instead of air, if some other liquid is blown into the flowing liquid (Fig 2b), the external liquid mixes with the flowing liquid and the mixture as a whole flows through the tube. Instead of air or liquid, if a solid block is inserted into the flowing liquid (Fig 2c), the solid block not only acts as an obstacle to the liquid flow but it also tends to damage the tube. In this way, whether the external induction acts as a useful flow-supporting mechanism, or as a to-be-flown medium, or as a flow-and-tube-disrupting device, depends onwhether the external inductor is in the gaseous phase, or liquid phase, or solid phase.

Just as in the case of the foregoing analogy (of gas on liquid in solid), an organ of a living body is similar to the solid-walled tube of the new analogy (of gas/liquid/solid on liquid in solid); nutrient inside the organ is similar to the liquid flowing through the tube; a drug taken inside the organ is similar to the external inductor blown onto the liquid into the tube. The behavior characteristic with respect to the dose volume in the case of a drug in an organ is similar to the behavior characteristic with respect to the phase in the case of an external inductor into a tube.

Transitions of Drug Phases

Let us now compare the first analogy (of gas on liquid in solid) with the second analogy (of gas/liquid/solid on liquid in solid). If a drug is little in quantity, it acts as a medicine; this phase of the drug is akin to the little-gas phase of the inductor of the first analogy and the gaseous phase of the inductor of the second analogy. If the drug is much in quantity, it acts as a nutrient; this phase of the drug is akin to the much-gas phase of the inductor of the first analogy and the liquid phase of the inductor of the second analogy. If the drug is too much in quantity, it acts as a poison; this phase of the drug is akin to the too-much-gas phase of the inductor of the first analogy and the solid phase of the inductor of the second analogy.

Relative density of the drug may be defined as the ratio of mass of the drug to volume of the organ to be acted upon. The drug is in a gas-like (medical) or liquid-like (nutritive) or solid-like (poisonous) phase depending upon whether the drug relative density is small or medium or high.

For a gas to become a liquid, more of gas molecules have to be pumped into the same volume to enhance the density. Similarly for a drug to transit from its gas-like medical phase to its liquid-like nutritive phase, more of drug molecules have to be pumped into the organ.

For a liquid to become a solid, more of liquid molecules have to be pumped into the same volume to enhance the density. Similarly for a drug to transit from its liquid-like nutritive phase to its solid-like poisonous phase, more of drug molecules have to be pumped into the organ.

Coherence-Tension Theory for Drug Phases

When an external drug is taken into a living body, the drug comes across a body organ and an internal nutrient working inside/for the organ. Characteristics of interaction of the drug on the internal nutrient and the organ depend inter-alia upon the drug quantity. This dependence can be explained as follows on the basis of coherence and tension. The explanation employs a provable assumption that the action of a material on another material leads to an equal reaction involving rearrangement of the reacting material in the form of revised units numbering equal to the number of units of the acting material; the unit being used to indicate a coherent base structure.

Until the drug quantity is relatively less than the internal nutrient quantity (Fig 3a), the drug consists of very few drug units. The conglomeration of the organ and the internal nutrient, which so far had numerous O-phase units, now gets rearranged into very few M-phase units, with each M-phase unit consisting of many O-phase units. This leads to a coherence and unification of O-phase units of the internal nutrient and the organ, and the internal nutrient and the organ undergo a cooperative tension to combat the drug penetration. Under this condition of cooperative tension, the effectiveness of the internal nutrient towards the organ is enhanced, and the organ being under a concentrated attention towards the internal nutrient undergoes suppression of the effect of painful subunits and thereby a healing process. Here energy flows from the paining component of the organ to the interjoint of the internal nutrient and the organ. This is the medical phase (M phase) of the drug, in which the drug shows actions like a medicine for the organ.

When the drug quantity becomes relatively comparable with the internal nutrient quantity (Fig 3b), the number of drug units increases. The conglomeration of the organ and the internal nutrient, which so far had very few M-phase units, now gets rearranged into several N-phase units, with each M-phase unit divided into several N-phase units and the number of N-phase units being comparable to the number of drug units. This reduces the coherence and unification of the internal nutrient and the organ, and the internal nutrient undergoes an internal tension to absorb the drug and the organ is left to its own course. Under this condition of internal tension, the strength of the internal nutrient as a nutrient for the organ is supplemented by an absorption of the drug, and the organ being under a forced attention towards itself is unable to undergo any healing process. Here energy flows from the drug to the internal nutrient. This is the nutritive phase (N phase) of the drug, in which the drug stops showing actions like a medicine and instead shows actions like a nutrient for the organ.

When the drug quantity becomes relatively higher than the internal nutrient quantity (Fig 3c), the number of drug units becomes sizable. The conglomeration of the organ and the internal nutrient, which so far had several N-phase units, now gets fragmented into large number of P-phase units, with each N-phase unit divided into several P-phase units and the number of P-phase units being comparable to the number of units of the drug. This enhances the incoherence and division of the internal nutrient and the drug, and the drug exerts a reverse tension to absorb the internal nutrient along with the organ. Under this condition of reverse tension, the strength of the internal nutrient as a nutrient for the organ is destroyed because of the absorption by the drug, and the organ being under an attack-like absorption by the drug undergoes a destruction process. Here energy flows from the organ to the drug. This is the poisonous phase (P phase) of the drug, in which the drug stops showing actions like a medicine or nutrient and instead shows actions like poison for the organ.

Implications of the Proposal

It is known in homeopathy that an inorganic or organic material acts as a medicine if it is taken below a certain limit by a patient suffering from a certain disease, but the same inorganic or organic material acts as a poison if it is taken above a certain limit by a healthy person. The proposal presented in this paper throws some light on this so-far-unexplained "homeopathic phenomenon". In fact this homeopathic phenomenon may be viewed just as a special case of the medical-nutritive-poisonous (MNP) phasing of a drug in an organ.

Besides this, the following important implications follow from the present proposal:

  1. Little-more-than-prescribed medicine acts as a nutrient and does not harm.

  2. Too much medicine acts as a poison and deteriorates the body and hence must be avoided.

  3. More-than-starving but less-than-desired food acts as a medicine and keeps the body healthy.

  4. More-than-enough food acts as a poison and deteriorates the body and must be avoided.

  5. Little alcohol is very useful, some alcohol good, much alcohol is harmful.

  6. Intake of nominal quantity of poison may improve health.

  7. The medical practice should be more control oriented and less consumption oriented.

Figure 1: Air on Liquid in Solid

Case a: Little Air; Case b: Much Air; Case c: Too Much Air

wpeFC.jpg (30575 bytes)

Figure 2: Air / Liquid / Solid on Liquid in Solid

Case a: Air; Case b: Liquid; Case c: Solid

wpeFD.jpg (22864 bytes)

Figure 3: Drug on Nutrient in Organ

Case a: Little Drug; Case b: Much Drug; Case c: Too Much Drug

wpeFE.jpg (16903 bytes)

References

  1. The Feynman Lectures on Physics (RP Feynman, RB Leighton, M Sands) Addison Wesley 1965

  2. Biophysics- Concepts and Mechanisms (EJ Casey) VanNostrand Reinhold 1962

  3. Chemobiodynamics and Drug Design (FW Scheuler) McGraw Hill 1961

  4. Histones as Regulators of Genes (M Grunstein) Scientific American 267/4, p 68, 1992

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Updated 19 May 2001

 

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